Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Mortality
Systematic review	916 people with acute cholecystitis 9 RCTs in this analysis	Mortality 1/468 (0.2%) with early open cholecystectomy 7/448 (1.6%) with delayed open cholecystectomy	OR 0.53 95% CI 0.17 to 1.66		Not significant
Systematic review	228 people with acute cholecystitis 3 RCTs in this analysis	Mortality 0/119 (0%) with early laparoscopic cholecystectomy 0/109 (0%) with delayed laparoscopic cholecystectomy	Reported as not significant P value not reported		Not significant
Systematic review	1014 people with acute cholecystitis 10 RCTs in this analysis 6 RCTs included in review	Mortality with early cholecystectomy (open and laparoscopic) with delayed cholecystectomy (open and laparoscopic) Absolute results not reported	Risk difference −0.01 95% CI −0.03 to 0.00		Not significant
Systematic review	451 people with acute cholecystitis 5 RCTs in this analysis	Mortality with early laparoscopic cholecystectomy with delayed laparoscopic cholecystectomy	Significance not assessed