Table 2.
Cytotoxicity (IC50) of metal complexes against MRC-5 cell line
| Compound | IC50 (μM)a |
|---|---|
| 8HQ (1) | 6.27±0.58 |
| 5Nu (2) | Noncytotoxicb |
| 5Iu (3) | Noncytotoxicb |
| 8HQ–Ni–5Nu (4) | NTc |
| 8HQ–Mn–5Nu (5) | 5.19±1.26 |
| 8HQ–Cu–5Nu (6) | 0.74±0.04 |
| 8HQ–Ni–5Iu (7) | NTc |
| 8HQ–Mn–5Iu (8) | NTc |
| 8HQ–Cu–5Iu (9) | NTc |
| Doxorubicin | Noncytotoxicb |
Notes:
a
Data are presented as mean ± standard deviation, n=3
b
noncytotoxic denotes compounds with IC50 >50 μg/mL
c
insoluble in testing medium.
Abbreviations: 5Iu, 5-iodouracil; 5Nu, 5-nitrouracil; 8HQ, 8-hydroxyquinoline; NT, not tested.