Table I. Patient-reported outcomes of quality of life (QoL), functioning, and depressive symptom severity. DSM-IV, Diagnostic and Statistical Manual of Mental Disorders—IV; MDD, major depressive disorder; SD, standard deviation; WHO, world Health Organization.

Name	Time to complete	Number of items	Item scale	Score range	Higher score is	Summary
QoL patiente-reported outcomes
Q-LES-Q Quality of Life, Enjoyment, and Satisfaction Questionnaire—Short Form	5 min	16	1-5	0-100	Better	The Q-LES-Q assesses QoL covering the following domains: health, mood, work, household activities, social and family relationships, leisure, ability to function daily, sex, economic and living situation, mobility, vision, wellbeing, medications, and overall satisfaction. The total score is calculated as the sum of scores from items 1 through 14 and is converted to a percentage using the following calculation: ([raw socre-14]/56) x 100. Community norms scores had a mean of 78.3%19
SF-36 Medical outcomes study—Short Form 36	15 min	36	0-5	0-100	Better	The SF-36 and its brief form the SF-12 measure QoL on eight health concepts:
						1. Limitations in physical activities because of health problems,
						2. Limitations in social activities because of physical or emotional problems,
SF-12 Medical outcomes study—Short Form 12	5 min	12				3. Limitations in usual role activities because of physical health problems,
						4. Bodily pain.
						5. General mental health (psychological distress and well-being).
WHOQOL WHO Quality of Life	25 min	100	1-5	0-100	Better	The WHOQOL and its brief form the WHOQOL-BRF are focused around the definition of QoL advocated by WHO; this includes the culture and context that influence an individual's perception of health. They measure four domains: physical health, psychological health, social relationships, and environment.21
WHOQOL-BREF 26-item version	10 min	26
EQ-5D EuroQoL	3 min	5	1-3	-1.0 to 1.0	Better	The EQ-5D measures QoL using five single-item measures of mobility, self-care, usual activities, pain/discomfort, and anxiety/depression. Scores range from 1.0 (perfect health) to -1.0 (death). It has an additional visual analog scale ranging from 0 (worst imaginable health state) to 100 (best imaginable health state).22
PROMIS-GHS Patient-Reported Outcomes Measurement Information System Global Health Scale	5 min	10	0-3	0-100	Better	The PROMIS-GHS measures health and QoL by assessing five primary domains: physical function, fatigue, pain, emotional distress, and social health. Scoring results in a “pgysical health” component and a “mental health” component each with a mean of 50 (SD, 10), where higher or lower scores indicate better or worse health than the population.23
Functioning patient-reported outcomes
WSAS Work and Social Adjustment Scale	3 min	5	0-8	0-40	Worse	The WSAS measures functioning in the work, home management, private leisure, social leisure, and relationship domains. The sum of the scores produces a total score where a score >20 indicates major functional impairment, 10-20 indicates significant functional impairment, and scores <10 are within normal range.24
WHODAS 2.0 WHO Disability Assessment Schedule 2.0	15 min	36	0-3	0-100	Worse	The WHODAS 2.0 and its brief 12-item version measure functioning in: cognition (understanding and communicating); mobility (moving and getting around); self-care (hygiene, dressing, eating, and staying alone); getting along (interacting with other people); life activities (domestic responsibilities, leisure, work, and school); and participation (joining in community activities). Scoring utilizes one of two methods: simple scoring involves simple sum of the score, and complex scoring uses a script converting the score using item-response theory to a range from 0 (no disability) to 100 (total disability).25
WHODAS 2.0 12-item version	5 min	12
SDS Sheehan Disability Scale	3 min	3	0-10	0-30	Worse	The SDS assesses functioning in the domains of work, social life, and family life/home responsibilities. The sum of the scores lead to a total score ranging from 0 (unimpaired) to 30 (highly impaired). Scores ≥5 on any of the domains or total score ≥8 are indicative of functional impairment.26
EWPS Endicott Work Productivity Scale	10 min	25	0-4	0-100	Worse	The EWPS covers twenty-five aspects of work/job functions such as being on time, accomplishing tasks, and performance. The item scores are summed up to a total score that ranges from 0 (no impairment) to 100 (major impairment in word productivity).27
Depressive symptom severity patient-reported outcomes
QIDS-SR Quick Inventory of Depressive Symptomatology—Self Report	10 min	16	0-3	0-27	Worse	The QIDS-SR measures the severity of 16 depressive symptoms. The total score is a sum of the highest score on any one of four sleep items (1-4) + item (5) + the highest score on any one appetite/weight item (6-9) + items (10-14) + the highest score on either of the two psychomotor items (15 and 16). Severity of MDD depressive symptoms is categorized based on the QIDS-SR scores: 0-5 (remission), 6-10 (mild), 11-15 (moderate), 16-20 (severe), or >20 (very severe).28
BDI-II Beck Depression Inventory II	10 min	21	0-	0-6	Worse	The BDI-II measures the severity of 21 depressive symptoms. The total score is the sum of all items. Depression severity is categorized with scores of 0-13 (minimal depression), 14-19 (mild depression), 20-28 (moderate depression), 29-63 (severe depression).29
CUDOS Clinically Useful Depression Outcome Scale	5 min	18	0-4	0-64	Worse	The CUDOS rates 16DSM-IV depression symptoms from “not at all true” (0 days) to “almost always true” (every day), item 17 rating inteference with functioning, and item 18 rating quality of life. The total score is the sum of the first 16 items, ranging from 0-10 (nondepresed), 11-20 (minimal depression), 21-30 (mild depression), 31-45 (moderate depression), or 46 and above (severe depression).30
CES-D Center for Epidemologic Studies Depression Scale	10 min	20	0-3	0-60	Worse	The CES-D measures the severity of 20 depressive symptoms from “rarely” to “most of the time”. The score is the sum of the 20 questions. A score of 16 points or more is considered as “depressed”.31
PHQ-9 Patient Health Questionnaire	5 min	9	0-3	0-27	Worse	The PHQ-9 measures the nine depressive symptoms from the DSM-IV. The total score is the sum of the nine items with scores of 1-4 (minimal depression), 5-9 (mild depression), 10-14 (moderate depression), 15-19 (moderately severe depression), or 20-27 (severe depression).32
PROMIS Depression Patient-Reported Outcomes Measurement Information system Depression Scale	5 min	8	1-5	0-100	Better	The PROMIS Depression scale measures negative mood, view of self, social cognition, decreased positive affect, and engagement. The raw score is then converted to a T score that has a population mean of 50 (SD, 10).33