Table II. Proportions of patients with normal quality of life (QoL) and functioning before and after each intervention. Normal QoL is defined as Q-LES-Q-SF scores within 10% of community norms, and severe impairment is defined as Q-LES-Q-SF scores greater than 2 standard deviations (SD) below the community norms. Since community norm samples have an average Q-LES-Q-SF of 78.3 (SD, 11.3), a Q-LES-Q-SF≥70.47 is considered within normal and a Q-LES-Q-SF≤55.7 is considered severely impaired.^19,46,47 Normal functioning is defined as WSAS scores of less than 10 and severe impairment is defined as WSAS scores of more than 20.²⁵ n, number.

Intervention	n	Within normal QoL Pre (%)	Within normal QoL Post (%)	Mcnemar Test P value	Severely impaired QoL Pre (%)	Severely impaired QoL Post (%)	Mcnemar test P Value
Bupropion	121	5.0	20.7	0.0002	84.3	68.6	0.002
Sertraline	131	0	17.6	<0.0001	89.1	62.6	<0.0001
Venlafaxine	121	1.7	14.0	0.0003	89.3	61.2	<0.0001
Cognitve therapy	32	3.1	31.3	0.012	84.4	43.8	0.001
Citalopram +bupropion	148	4.1	23.6	<0.0001	75.0	53.4	<0.0001
Citalopram +buspirone	149	4.0	22.1	<0.0001	77.2	55.0	<0.0001
Citalopram+cognitve therapy	47	2.1	6.4	0.63	93.6	68.1	0.004
All	749	2.9	19.5	<0.0001	83.3	59.5	<0.0001
Intervention	n	Within normal functioning Pre (%)	Within normal functioning Post (%)	Mcnemar Test P value	Severely impaired functioning Pre (%)	Severely impaired functioning Post (%)	Mcnemar test P value
Bupropion	121	6.6	25.6	<0.0001	64.5	47.9	0.0008
Sertraline	131	5.3	31.3	<0.0001	65.6	49.6	0.002
Venlafaxine	121	1.7	28.1	<0.0001	66.1	45.5	0.0001
Cognitve therapy	32	3.1	43.8	0.0002	65.6	37.5	0.012
Citalopram +bupropion	148	11.5	39.2	<0.0001	58.8	41.9	0.0003
Citalopram +buspirone	149	8.1	34.2	<0.0001	57.7	39.6	<0.0001
Citalopram +cognitive therapy	47	2.1	21.3	0.012	66.0	44.7	0.031
All	749	6.4	31.9	<0.0001	62.6	44.3	<0.0001