Table III. Comparisons for 749 patients with both pre- and post-treatment values using the Individual Burden of Illness for Depression (IBI-D). Values are means (standard deviation [SD]). Paired t test (within intervention change: exit vs base). P=0.082 (nonsignificant [NS]) for difference in base to exit change between interventions, confirmed by Welch's analysis of variance (ANOVA; P=0.143; NS). n, number.

			All				Remitters					Nonremitters
Intervention	n	IBI-D Pre	IBI-D Post	IBI-D Change	P	n	IBI-D Pre	IBI-D Post	IBI-D Change	P	n	IBI-D Pre	IBI-D Post	IBI-D Change	P
Bupropion	121	-0.02 (1.07)	-0.67 (1.44)	-0.66 (1.21)	<0.0001	26	-0.58 (1.03)	-2.40 (0.78)	-1.82 (1.12)	<0.0001	95	0.14 (1.03)	-0.20 (1.19)	-0.34 (1.02)	<0.0001
Sertraline	131	0.04 (0.95)	-0.79 (1.43)	-0.83 (1.15)	<0.0001	35	-0.54 (0.93)	-2.50 (0.60)	-1.96 (0.82)	<0.0001	96	0.25 (0.87)	-0.16 (1.10)	-0.42 (0.97)	<0.0001
Venlafaxine	121	0.08 (0.92)	-0.81 (1.35)	-0.89 (1.08)	<0.0001	34	-0.32 (0.79)	-2.22 (0.63)	-1.90 (0.91)	<0.0001	87	0.24 (0.93)	-0.26 (1.13)	-0.49 (0.86)	<0.0001
Cognitive therapy	32	-0.12 (0.85)	-1.32 (1.41)	-1.20 (1.46)	<0.0001	12	-0.13 (0.94)	-2.68 (0.44)	-2.55 (1.07)	<0.0001	20	-0.11 (0.82)	-0.50 (1.12)	-0.39 (0.99)	<0.0001
Citalopram + Bupropion	148	-0.34 (0.94)	-1.14 (1.35)	-0.80 (1.09)	<0.0001	53	-0.77 (0.77)	-2.40 (0.64)	-1.64 (0.88)	<0.0001	95	-0.11 (0.95)	-0.44 (1.11)	-0.33 (0.91)	<0.0001
Citalopram + Buspirone	149	-0.30 (0.98)	-0.90 (1.42)	-0.59 (1.07)	<0.0001	38	-0.76 (072)	-2.30 (0.66)	-1.54 (0.90)	<0.0001	111	-0.15 (1.01)	-0.42 (1.29)	-0.27 (0.93)	<0.0001
Citalopram + Cognitive therapy	47	-0.14 (0.86)	-0.86 (1.09)	-0.72 (1.14)	<0.0001	10	-032 (0.73)	-2.22 (049)	-1.90 (0.79)	<0.0001	37	-0.10 (0.89)	-0.49 (0.90)	-0.40 (1.01)	<0.0001
All	749