Table 2.
Association analysis between the number of α3.7-globin deletions and malaria parasite positivity using complete case data. “Log-likelihood” refers to the maximum value of the log-likelihood function after maximum likelihood parameter estimation. Association analysis was performed adjusting or not for putative confounders (age, gender, ethnicity, altitude, and transect). Association signals refer to −log10(p-value), where p-value is from Pearson's χ2 test for two-way contingency tables in the unadjusted analysis, and from the likelihood ratio test for lack of genetic association in the adjusted analysis
| Unadjusted analysis | Adjusted analysis | |||
|---|---|---|---|---|
| Parameter | Estimate | SE | Estimate | SE |
| Average no. of deletions | 0.337 | 0.010 | − | − |
| λ1 | 0.408 | 0.121 | −0.225 | 0.138 |
| λ2 | 1.165 | 0.250 | 0.179 | 0.283 |
| Log-likelihood | −1069.16 | − | −876.99 | − |
| Association signal | 5.71 | − | 0.80 | |