Scheme 1. Attempted Synthesis of Saponin 1a.
aReagents and conditions: (a) FmocCl, Pyr, DMAP, 0 °C to room temperature, 87%. (b) Diosgenin, NIS, TMSOTf, CH2Cl2, −42 °C, 75%. (c) TMSOTf, CH2Cl2, 0 °C, 88% for 6; 27% for 8. (d) Et3N, 85% from 5.
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.