Table 2. CYP Inhibition of Designed Compounds.

		inhibition (%)
compda	clogPb	CYP3A4	CYP2D6	CYP1A2	CYP2C9	CYP2C19
3	3.29	80	24	64	84	81
4	2.27	52	7	72	69	29
10	2.51	16	18	93	32	36
12	1.83	24	14	95	54	42
15	3.53	64	25	87	65	55
19	1.87	6	16	95	9	8

^aAll compounds were tested at 10 μM concentration.

^bCalculated by Molinspiration.