Figure 4.

Effects of 34 on motor activity in mice. Mice had been habituated for 60 min before injection. Compound 34 was dissolved in 10% Cremophor EL (vehicle) and injected (ip) 10 min before NPS or vehicle (PBS, 0.1% BSA) were injected centrally (icv). Group sizes: Veh + Veh, n = 8; Veh + NPS, n = 7; 34 + PBS, n = 7; 34 (50 mg/kg) + NPS (1 nmole), n = 8; 34 (5 mg/kg) + NPS (1 nmole), n = 9. (A) Time course of the distance traveled over 90 min. (B) Total distance traveled during the 90 min observation period. *, p < 0.001, Veh + Veh versus Veh + NPS; #, p < 0.001 Veh + NPS versus NPS + 34 (50 mg/kg) (Students t test).