Table 1.
Characteristics of patients with lower limb ischaemia treated with thrombolysis in Malmö and Uppsala
| All procedures (n = 749) | Acute arterial thrombosis (n = 232) | Embolus (n = 161) | Popliteal aneurysm (n = 48) | Graft occlusion (n = 280) | P† | |
|---|---|---|---|---|---|---|
| Centre | <0.001 | |||||
| Malmö | 431 (57·5) | 122 (29·0) | 75 (17·8) | 24 (5·7) | 200 (47·5) | |
| Uppsala | 318 (42·5) | 110 (36·7) | 86 (28·7) | 24 (8·0) | 80 (26·7) | |
| Mean age (years) | 71·6 | 70·8 | 77·5* | 70·4 | 68·8 | <0.001 |
| Sex ratio (M : F) | 396 : 353 | 116 : 116 | 70 : 91* | 45 : 3* | 152 : 128 | <0.001 |
| Co-morbidities | ||||||
| Hypertension | 484 (64·6) | 151 of 231 (65·4) | 99 (61·5) | 24 (50) | 189 (67·5) | 0.103 |
| Diabetes | 135 (18·0) | 57 (24·6)* | 25 (15·5) | 2 (4)* | 47 (16·8) | 0.003 |
| Ischaemic heart disease | 243 (32·4) | 56 of 231 (24·2)* | 60 (37·3) | 14 (29) | 106 (37·9) | 0.005 |
| Atrial fibrillation | 217 (29·0) | 37 of 231 (16·0)* | 104 (64·6)* | 6 (13) | 61 (21·8)* | <0.001 |
| Cerebrovascular disease | 100 (13·4) | 29 of 231 (12·6) | 26 (16·1) | 7 (15) | 33 (11·8) | 0.599 |
| Renal insufficiency | 243 (32·4) | 65 of 227 (28·6) | 71 (44·1)* | 12 (25) | 86 of 275 (31·3) | 0.005 |
| Anaemia | 214 (28·6) | 66 of 224 (29·5) | 47 of 158 (29·7) | 11 (23) | 80 of 274 (29·2) | 0.853 |
| Medications | ||||||
| Aspirin | 400 (53·4) | 101 (43·5)* | 84 (52·2) | 19 (40) | 185 of 279 (66·3)* | <0.001 |
| Warfarin | 113 (15·1) | 18 (7·8)* | 28 (17·4) | 1 (2)* | 64 (22·9)* | <0.001 |
| Degree of ischaemia | ||||||
| Mean duration of symptoms (h) | 254 | 447* | 99 | 157 | 210 | <0.001 |
| Motor deficit | 155 (20·7) | 46 of 221 (20·8) | 39 of 154 (25·3) | 15 of 47 (32) | 48 of 271 (17·7) | 0.080 |
| Acute limb ischaemia | 589 (78·6) | 150 (64·7)* | 160 (99·4)* | 45 (94)* | 216 (77·1) | <0.001 |
| Critical limb ischaemia | 92 (12·3) | 60 (25·9)* | 1 (0·6)* | 1 (2) | 23 (8·2) | <0.001 |
| Claudication | 68 (9·1) | 22 (9·5) | 0 (0)* | 2 (4) | 41 (14·6)* | <0.001 |
Values in parentheses are percentages of all procedures or of the relevant aetiological group. In 28 patient records the information regarding aetiology of occlusions was missing and these patients were not included in the comparisons between aetiological groups.
*
P <0·010 versus other groups;
†
comparisons of all groups (cross-tabulation with χ2 test for dichotomous variables and one-way ANOVA for continuous variables).