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. Author manuscript; available in PMC: 2014 Aug 21.
Published in final edited form as: Endocrinology. 2005 Aug 4;146(11):4647–4656. doi: 10.1210/en.2005-0670

Fig. 7.

Fig. 7

Effect of FGF23 on NPT2a mRNA expression. A, OK cells were treated over 24 h with either vehicle (CTL), PTH (100 nM), or FGF23 (100 nM) with or without 2 µg/ml N,O-SH, and the effects on Npt2a mRNA were examined. FGF23 robustly decreased Npt2a mRNA expression, and its effect did not require N, O-SH [P < 0.001 vs. control (CTL)]. PTH, included as a positive control, had a similar effect. B, OK cells were treated with sodium chlorate (50 mM) to block sulfation of GAGs. PTH or FGF23 was added with or without 2 µg/ml N, O-SH or HS-M. In this condition, the effect of FGF23 on Npt2a mRNA became sensitive to exogenousN, O-SH. a, P < 0.05 vs. CTL; b, P < 0.05 vs. FGF23 alone; c,P < 0.05 vs. heparin alone.