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. Author manuscript; available in PMC: 2014 Aug 21.
Published in final edited form as: Brain Struct Funct. 2012 Nov 18;219(1):35–47. doi: 10.1007/s00429-012-0482-6

Figure 8.

Figure 8

Zebrin II expression reveals parasagittal stripes in the hemispheres of dreher mice. (A) In control cerebella, at least six zebrin II immunopositive stripes occupy the hemispheres (P4a+, P4b+, P5a+, P5b+, P6+ and P7+). The broad P5b+ and P6+ are heavily reactive and are easiest to identify on whole mount immunoperoxidase-stained cerebella. (B) P5b+ and P6+ are the most obvious stripes in the hemispheres of the dreher cerebellum as seen on whole mount immunoperoxidase-stained cerebella: P4+ and P7+ are resolved with less clarity. (C) In control cerebella zebrin II is expressed in all Purkinje cells in the flocculus (see also Eisenman and Hawkes 1993). (D) Zebrin II is also expressed in all Purkinje cells the dreher cerebellum. (E) In wild type cerebella HSP25 is expressed in a subset of Purkinje cells in the flocculus/paraflocculus complex (pfl/fl; for details see Armstrong and Hawkes 2001). (F) An example of an HSP25 immunoperoxidase-stained transverse section through the flocculus/paraflocculus in dreher showing that HSP25 is expressed by a subset of Purkinje cells in the paraflocculus. Scale bar = 1 mm in A (also applies to B); 50 μm in F (also applies to C, D, E).