Table 1. Quantified rigid and flexible binding energy landscapes.

PDB	1cop		1lmb		1lfb		3mus		1xso
	Ind a	Eff	Ind	Eff	Ind	Eff	Ind	Eff	Ind	Eff
	57.56	57.02	48.89	48.03	49.70	49.19	40.63	40.41	59.31	59.35
	11.01	5.37	9.92	5.77	8.09	4.89	7.00	5.58	8.74	7.57
	42.12	74.58	40.67	64.00	43.27	67.79	41.36	53.47	47.11	62.03
	1.95	0.97	1.59	0.92	1.62	0.98	1.39	0.97	1.66	1.21
	1.20	0.44	1.10	0.51	0.87	0.42	0.77	0.54	0.90	0.68
	1.62	2.20	1.45	1.80	1.86	2.33	1.80	1.79	1.84	1.78
	9.92	7.08	9.70	7.64	9.44	7.50	7.92	7.08	7.64	9.21
	0.56	0.86	0.54	0.73	0.66	0.86	0.63	0.69	0.69	0.70
	0.18		0.17		0.16		0.12		0.09

Energy is in reduced unit; Temperature is in energy unit.

^a“Ind” and “Eff” are the abbreviations for “Independent” and “Effective” binding, respectively.