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Experimental groups investigated in this study. Growth factors were loaded into gelatin microparticles prior to encapsulation within bilayered OPF hydrogels.
| Experimental Groups | IGF-1 | BMP-2 | Both |
|---|---|---|---|
| Chondral Layer (Top 1mm) | IGF-1 | Blank | IGF-1 |
| Subchondral Layer (Bottom 2mm) | Blank | BMP-2 | BMP-2 |
|
| |||
| 6 Week Repetitions | 12 | 10 | 12 |
| 12 Week Repetitions | 12 | 11 | 12 |
