Figure 6. Differential Th2 polarizing capacities of differently matured moDC.

Naive CD4⁺ T cells were co-cultured for 7 days with PGE₂/TNF-α (dark gray triangle), LPS/IFN-γ (light gray circle) or FMKp/IFN-γ (black square) matured DC. Expression of GATA3, IL-4, IL-5 and IL-13 and production of IL-5 and IL-13 were monitored. IL-5 and IL-13 protein production by naive T cells co-cultured with differently matured DC was determined in the supernatant of the co-culture. Graphs are representative of 5 independent experiments.