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. 2014 Aug 21;9(8):e104675. doi: 10.1371/journal.pone.0104675

Figure 6. Sox17 regulates pathways involved in insulin transport and secretion.

Figure 6

A) Analysis of transcriptional changes in islets after 24 hours of Sox17 overexpression by microarray. The heat map highlights the Sox17-regulated transcripts (upregulated genes in red, downregulated genes in blue, n = 3 per genotype). B–D) Quantitative-RTPCR validation of transcripts that were up- or down-regulated in response to Sox17 including Glp-1 receptor (Glp1R), protein kinase C isoform a (Prkca), Reticulon 1 (Rtn1), all of which are known regulators of secretory pathway. E) Schematic representation of Sox17-regulated factors and their known involvement in the insulin processing and secretory pathways. Genes that were upregulated by Sox17 expression are shown in red, and those that were down regulated are shown in blue.