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. Author manuscript; available in PMC: 2014 Aug 21.
Published in final edited form as: N Engl J Med. 2012 Dec 27;367(26):2495–2504. doi: 10.1056/NEJMoa1208506

Table 4.

Visual Outcome at 18 to 22 Months of Corrected Age in the Lower-Oxygen-Saturation and Higher-Oxygen-Saturation Groups.*

Variable Lower Oxygen
Saturation
Higher Oxygen
Saturation
Adjusted Relative Risk
(95% CI)
P Value
number/total number (percent)
Strabismus 46/478 (9.6) 41/510 (8.0) 1.20 (0.80–1.80) 0.38

Nystagmus 22/479 (4.6) 13/510 (2.5) 1.81 (0.89–3.69) 0.10

Eyes track 180 degrees 462/476 (97.1) 493/507 (97.2) 1.00 (0.98–1.02) 0.93

Corrective lenses for both eyes 21/468 (4.5) 20/493 (4.1) 1.15 (0.63–2.10) 0.65

Blind with some function in both eyes 3/450 (0.7) 2/475 (0.4) 1.57 (0.27–8.96) 0.61

Blind with no useful vision in both eyes 2/449 (0.4) 4/477 (0.8) 0.54 (0.10–2.96) 0.48

Other abnormal eye finding 6/453 (1.3) 12/485 (2.5) 0.55 (0.21–1.46) 0.23

Blind in at least one eye 5/479 (1.0) 8/511 (1.6) 0.67 (0.22–2.02) 0.48

Eye surgery performed§ 31/477 (6.5) 67/509 (13.2) 0.53 (0.35–0.78) 0.002
*

Relative risks and P values were adjusted for stratification factors (study center and gestational-age group) and familial clustering; analyses of blindness and other abnormal eye finding were not adjusted for study center, owing to the small numbers of patients with these characteristics.

The reference group for relative risk was the group of children with vision that appeared to be normal in both eyes.

Other abnormal eye finding was defined as an abnormality other than a condition requiring corrective lenses but not one severe enough for the child to be considered blind in that eye. Children whose eyes were classified in two different vision categories were included in the other-abnormal-eye-finding category.

§

Reasons for surgery are listed in Table S5 in the Supplementary Appendix.