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. 2014 Aug 16;9:3923–3935. doi: 10.2147/IJN.S62263

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© 2014 Liu et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Brain uptake of LTG after IV administration of free LTG and P123/LTG at 30 minutes, 60 minutes, and 240 minutes at a dose of 10 mg LTG/kg body weight.

Notes: (A) Percentages of the injected dose per gram (%ID/g) of brain tissue and (B) Brain:plasma ratios are shown. Data shown are presented as the means ± SEM from 5–6 animals per group. *P<0.05, **P<0.01 against the LTG group.

Abbreviations: LTG, lamotrigine; ID%/g, injected dose per gram; IV, intravenous; SEM, standard error of the mean.