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. 2014 Aug 16;9:3923–3935. doi: 10.2147/IJN.S62263

Figure 7.

Figure 7

The qualitative evaluation of Rho 123-incorporated polymeric micelles in vivo.

Notes: Distribution of micelles in the brains of SD rats treated with polymeric micelles (IL) and free Rho 123 (AD) 30 minutes after IV administration. The middle row (EH) shows Rho 123 brain distribution in rats pretreated with verapamil (20 mg/kg, IP) 90 minutes before free Rho 123 administration. Frozen sections (thickness of 20 μm) of the cortical layer (A, E, I), hippocampus (B, F, J), substantia nigra (C, G, K), and caudate putamen (D, H, L) were examined by fluorescence microscopy. The sections were stained with 300 nM DAPI for 10 minutes at room temperature. Red: Rho 123. Blue: cell nuclei. Original magnification: ×200.

Abbreviations: SD, Sprague Dawley; IP, intraperitoneal; DAPI, 4′,6′-diamidino-2-phenylindole; IV, intravenous.