Figure 6. Protection and survival against L. donovani infection in immunized hamsters.
A–D, kinetics of liver (A) and spleen (B) parasite burden by LDU, liver LDA (C) and spleen LDA (D) of hamsters 2 and 3 months after intracardiac challenge of 2×107 virulent L. donovani promastigotes. Results are expressed as log of total organ parasite burden. Data represent the mean ± S.E. (n = 5/group). ***p<0.001 compared to adjuvant controls. Asterisks over line indicate significant differences between groups. E, Kaplan-Meier survival curves comparing survivality in different groups of vaccinated hamsters. Survival results are from 10 hamsters per group. Survival distribution was analyzed by log-rank (Mantel-Cox) test, and level of significance is indicated by P value.