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. 2014 Aug 21;8(8):e3095. doi: 10.1371/journal.pntd.0003095

Figure 2. Primary screening of protease inhibitor library.

Figure 2

Scatter plot of primary screening data where the percentage of infected cells was normalized with mock-treated, RVFV-infected cells to determine the percentage of infection inhibition. A collection of 849 compounds from the ChemDiv protease inhibitor library in 13 96-well plates were screened at a 20 µM concentration against RVFV MP12 strain in HeLa cells. Data from each of the 13 plates are represented by same color. Hit compounds having greater than 50% antiviral activity (represented by horizontal black line) were selected for secondary screening.