Table 2. Antiviral activity of the four hit compounds and reference compounds against VEEV, EBOV, MARV and LASV infected HeLa cells.
| Viruses | Compound | EC50 (µM) | CC50 (µM) | SI |
| VEEV | C795-0925 | 10.2 | 63.7 | 6.2 |
| VEEV | D011-2120 | 41.6 | 42 | 1.0 |
| VEEV | F694-1532 | 15.2 | 23.8 | 1.6 |
| VEEV | G202-0362 | 48.9 | ND | >4.1 |
| VEEV | ribavirin | 75 | ND | >2.7 |
| EBOV | C795-0925 | 46.6 | ND | >4.3 |
| EBOV | D011-2120 | 54.1 | 65.6 | 1.2 |
| EBOV | F694-1532 | 117.6 | ND | >1.7 |
| EBOV | G202-0362 | 16.1 | ND | >12.5 |
| EBOV | ribavirin | 60.1 | ND | >3.3 |
| MARV | C795-0925 | 57.4 | ND | >3.5 |
| MARV | D011-2120 | 87.1 | 90.6 | 1.0 |
| MARV | F694-1532 | 143.3 | 167 | 1.2 |
| MARV | G202-0362 | 34.1 | ND | >5.9 |
| MARV | ribavirin | 82.2 | ND | >2.4 |
| LASV | C795-0925 | 81.4 | 103.2 | 1.3 |
| LASV | D011-2120 | 46.8 | 47.2 | 1.0 |
| LASV | F694-1532 | 80.4 | ND | >2.5 |
| LASV | G202-0362 | ND | ND | ND |
| LASV | ribavirin | 6.8 | ND | >29.4 |
HeLa cells were infected with VEEV (MOI = 0.5 for 20 h), EBOV (MOI = 3 for 48 h), MARV (MOI = 3 for 48 h) or LASV (MOI = 1 for 24 h).
SI is determined by the formula: CC50/EC50.
ND, not determined.