Table 2. Factors Associated with Positive HBV Vaccine Seroresponse for HIV Controllers Compared to Non-controllers With or Without Viral Load-Suppressive HAART.
Characteristic | HIV Controllers vsHAART-naïve Non-Controllers (OR, 95% CI) | P-value | HIV Controllers vs Non-Controllers on HAART(OR, 95% CI) | P-value |
HIV Controller vs Non-Controller | 2.65 (1.23–5.89) | 0.014 | 1.16 (0.53–2.6) | 0.718 |
African-American vs Caucasian | 0.89 (0.54–1.47) | 0.662 | 1.38 (0.79–2.41) | 0.256 |
Hispanic/Other vs Caucasian | 1.76 (0.91–3.4) | 0.091 | 0.93 (0.43–2.02) | 0.847 |
Female vs Male | 1.44 (0.75–2.75) | 0.269 | 1.14 (0.56–2.38) | 0.717 |
Age at Last Vaccination(Per 10 years) | 0.75 (0.54–1.04) | 0.087 | 0.98 (0.76–1.26) | 0.884 |
CD4 Count at Last Vaccination(For Every 100 Cells/uL) | 1.28 (1.15–1.45) | <0.001 | 1.23 (1.1–1.38) | <0.001 |
Number of Vaccine Doses,≥3 vs 1–2 | 0.56 (0.35–0.88) | 0.011 | 1.11 (0.66–1.86) | 0.693 |
AIDS Before Last Vaccination | 0.84 (0.45–1.52) | 0.567 | 1.63 (0.91–3.0) | 0.107 |
HBV, hepatitis B virus; HAART, highly active antiretroviral therapy; OR, odds ratio; CI, confidence interval; AIDS, acquired immunodeficiency syndrome.
Data are number (%) or median (Interquartile Range).
Positive HBV vaccine seroresponse defined as antibody to HBV surface antigen ≥10 IU/L measured ≥1 month after last HBV vaccination.