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. 2014 Aug 21;9(8):e105636. doi: 10.1371/journal.pone.0105636

Figure 6. LPS up-regulated IFN-beta expression by activating NF-kappaB pathway.

Figure 6

(A and B) DCs were pretreated with the NF-kappaB kinase inhibitor 40 µM PDTC (A) or 20 µM Bay 11-7082 (B) 2 h prior to LPS (10 ng/ml) 12 h stimulation. The expression of IFN-beta was determined by flow cytometry. Numbers in histogram indicate MFI of analyzed population (left). Statistical analysis of IFN-beta positive percentages (middle) and MFI (right) was shown. The data are presented as the mean ± SEM, n = 3, **p<0.01, ***p<0.001, one-way ANOVA with Newman-Keulspost test. One representative from 3 independent experiments is shown.