Table 1. P. falciparum K13-propeller amino acid and nucleotide substitutions observed in Tororo, Uganda.
Codon | Propellerblade | Type | Referenceaminoacid | Mutantaminoacid | NucleotideLocus | Referenceallele | Mutantallele | n/N |
189a | - | NS | K | T | 566 | A | C | 10/29 |
189a | - | NS | K | N | 567 | A | T | 1/29 |
334 | - | NS | F | L | 1000 | T | C | 2/102 |
368a | - | Syn | L | L | 1104 | A | G | 1/101c |
439 | - | Syn | F | F | 1317 | T | C | 1/129 |
465 | 1 | NS | I | T | 1394 | T | C | 1/129 |
467 | 1 | Syn | Q | Q | 1401 | A | G | 1/131 |
522 | 2 | Syn | S | Sb | 1566 | T | C | 1/132 |
558 | 3 | NS | Y | H | 1672 | T | C | 1/133 |
578a | 4 | NS | A | S | 1732 | G | T | 1/133 |
617 | 5 | NS | A | T | 1849 | G | A | 1/133 |
619 | 5 | NS | L | S | 1856 | T | C | 1/133c |
637 | 5 | NS | V | Db | 1910 | T | A | 1/132 |
All data are relative to reference sequence PF3D7_1343700.
n = number of samples containing mutant allele.
N = number of samples sequenced at locus.
SNP has been previously identified (MalariaGen).
Different SNP in same codon has been previously reported (MalariaGen).
Polymorphism identified in mixed P. falciparum/P. ovale infection.