. 2014 Aug 21;9(8):e105690. doi: 10.1371/journal.pone.0105690

Table 2. P. falciparum FP2 non-synonymous amino acid and nucleotide substitutions observed in Tororo, Uganda.

Codon	ProteinDomain^f	Ref. AA	Mut. AA	Nuc.Locus	Ref.Codon	Mut.Codon	n/N(2010–12)	n/N(2006–07)	n/N(2012)
4^a ^, ^b	Pre-	N	H	10	AAC	CAC	8/73	-	-
8^a ^, ^b	Pre-	A	I^c	22–24	GCT	ATT	7/76	-	-
10^b	Pre-	H	N	28	CAT	AAT	8/78	-	-
15^a ^, ^b ^, ^d	Pre-	Q	H	45	CAA	CAT	9/80	-	-
51^b ^, ^d	Transmem.^e	V	I	151	GTT	ATT	14/90	-	-
55	Transmem.	F	I	163	TTT	ATT	1/90	-	-
59^b ^, ^d	Pro-	S	F	176	TCT	TTT	6/91	-	-
105^b	Pro-	S	N	314	AGT	AAT	2/152	0/22	0/107
107^a ^, ^b	Pro-	K	M	320	AAG	ATG	1/158	0/26	0/111
108^a ^, ^b	Pro-	N	K	324	AAT	AAA	1/158	0/28	0/111
113^a	Pro-	Y	N	337	TAC	AAC	1/158	0/33	0/111
115–122	Pro-	NEGNNNNNA	NNNNTLSD	342–369	-	-	1/158	0/33	0/111
134^b	Pro-	T	K	401	ACA	AAA	1/160	0/41	0/112
161	Pro-	H	R^c	482	CAT	CGT	1/160	0/44	0/112
169	Pro-	I	M	507	ATT	ATG	1/160	0/45	1/112
173^b	Pro-	N	K	519	AAT	AAA	1/160	0/45	0/112
197^b ^, ^d	Pro-	N	K	591	AAT	AAA	1/160	0/49	1/112
204^b ^, ^d	Pro-	N	K	612	AAT	AAG	1/160	0/49	1/112
210	Pro-	E	Q	628	GAA	CAA	0/160	1/49	0/112
228^b ^, ^d	Pro-	S	T	683	AGT	ACT	16/160	5/49	13/112
245^a	Pro-	M	I	735	ATG	ATA	1/160	0/49	1/112
248^a	Folding	E	D	744	GAA	GAC	1/160	0/49	1/112
249	Folding	E	A	746	GAA	GCA	1/160	0/49	1/112
249	Folding	E	D	747	GAA	GAC	1/160	0/49	1/112
255^b	Folding	K	G^c	763–764	AAA	GGA	6/160	2/49	4/112
255^b ^, ^d	Folding	K	R^c	764	AAA	AGA	152/160	46/49	106/112
257^b ^, ^d	Folding	N	E	769–771	AAT	GAA	158/160	48/49	110/112
299^b	Catalytic	A	V	896	GCT	GTT	0/160	1/49	0/112
310	Catalytic	E	D	930	GAA	GAC	1/160	0/49	0/112
335	Catalytic	M	I	1005	ATG	ATT	2/160	1/49	2/112
337	Catalytic	E	D	1011	GAA	GAT	1/160	0/49	1/112
343^b ^, ^d	Catalytic	T	P	1027	ACA	CCA	156/160	47/49	110/112
345^b ^, ^d	Catalytic	D	G	1034	GAT	GGT	157/260	47/49	111/112
365	Catalytic	K	T	1094	AAA	ACA	1/158	0/49	1/110
384^b	Catalytic	R	S	1152	AGA	AGC	0/158	1/49	0/110
393	Catalytic	V	I	1177	GTA	ATA	1/158	0/49	0/110
398	Catalytic	D	V	1193	GAT	GTT	0/158	1/49	0/110
414^b ^, ^d	Catalytic	Q	E	1240	CAA	GAA	41/157	15/47	27/109
414	Catalytic	Q	L	1241	CAA	CTA	1/157	0/47	1/109

All data are relative to reference sequence PF3D7_1343700.

n = number of samples containing mutant allele.

N = number of samples sequenced at locus.

SNP reported in MalariaGen.

SNP reported in PlasmoDB, v. 11.0.

Different SNP in same codon has been previously reported (MalariaGen or PlasmoDB).

SNP reported to be present in culture adapted Cambodian strains by Ariey et al.[14].

Transmembrane boundaries as indicated in PlasmoDB v. 11.0 (amino acids 35–57).