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. 2014 Aug 21;9(8):e105772. doi: 10.1371/journal.pone.0105772

Figure 5. Hydrogen sulfide increases the excitability of SFO neurons.

Figure 5

An analysis of rheobase and action potential firing frequency revealed an increase in excitability. (A) Current clamp trace with red bar indicating application of NaHS (1 mM), and blue bars (α and β) indicate periods when current injection protocol was performed. (B) The middle panel shows the current injection protocols for 2X and 3X rheobase steps, and 0–200 and 0–500 pA ramps, while the spike patterns induced are shown for the control (left panel, α) and NaHS (right panel, β) conditions. Bar graphs displaying the mean number of action potentials before (black) and during (grey) NaHS application for the current step (C) and ramp (D) protocols. Note the increase in action potential number in response to NaHS in all 4 cases. *p<0.05, paired t test.