Skip to main content
. 2014 Aug 21;10(8):e1004322. doi: 10.1371/journal.ppat.1004322

Figure 3. BGLF5 knockdown results in minimal increases in epitope recognition.

Figure 3

A) Relative recognition of donor 5 shBGLF5-LCLs, compared to shControl-LCLs, by a panel of HLA-A2 restricted CD8+ T cells specific for IE-YVL (BRLF1), E-GLC (BMLF1) and L-FLD (BALF4) epitopes. (B) Relative recognition of donor 6 shBGLF5-LCLs, compared to shControl-LCLs, by a panel of HLA-A2 restricted CD8+ T cells specific for IE-YVL (BRLF1), E-GLC (BMLF1) and L-WQW (BNRF1) epitopes. (C) Relative recognition of donor 3 HLA-B7 positive shBGLF5-LCLs, compared to Control LCLs, by HLA-B7 restricted T cells specific for the IE-DPY (BZLF1), E- RPG (BNLF2b) and L-YPR (BNRF1) epitopes. All representative data are shown as fold increase in recognition of shBGLF5-LCLs compared to shControl transduced LCL counterparts, following normalisation of T cell recognition (IFN-γ release) against the expression levels of the antigen from which each epitope is derived.