Figure 8. Relative recognition by IE- and L- specific, HLA-A2 restricted CD8+ T cell clones of LCLs lacking both BNLF2a and BILF1 expression.
A) Recognition of IE-YVL presented by donors 7 and 8 LCLs was measured simultaneously. T cell recognition (IFN-γ release) was normalised on the expression of BRLF1 mRNA transcript. Data are shown as recognition of single and double knockdown LCLs relative to shControl LCLs. (B) Recognition of L-FLD presented by each donor 7 and 8 LCLs was measured simultaneously. T cell recognition (IFN-γ release) was then normalised on the expression of BRLF1 mRNA transcript. Data are shown as recognition of single and double knockdown LCLs relative to recognition of shControl LCLs.