Table 3. Summary of fold increase in CD8+ T cell recognition of EBV-antigens presented by shBNLF2a-LCLs compared to shControl-LCLs.
Fold increase | ||||||
Expression phase of target antigen | Target antigen | Epitope | HLA restriction | Number of experiments* | Range | Median |
IE | BRLF1 | YVL | A2 | 11 | 6.5–30.7 | 17 |
IE | BZLF1 | DPY | B7 | 4 | 7–14 | 8.3 |
E | BMLF1 | GLC | A2 | 10 | 7–24 | 11.5 |
E | BMRF1 | TLD | A2 | 5 | 7.5–12 | 9 |
E | BNLF2b | RPG | B7 | 4 | 4.1–7 | 5.5 |
L | BALF4 | FLD | A2 | 11 | 2–5 | 2.3 |
L | BNRF1 | WQW | A2 | 4 | 2.3–3 | 2.5 |
L | BNRF1 | YPR | B7 | 4 | 2–3.5 | 2.5 |
* more than one effector clone specific for each epitope was used where possible. In total, seven different donor LCLs were used.