Table 5. Summary of fold increase in CD8 T cell recognition of EBV-antigens presented by shBILF1-LCLs compared to shControl-LCLs.
Fold increase | ||||||
Expression phase of target antigen | Target antigen | Epitope | HLA restriction | Number of experiments* | Range | Median |
IE | BRLF1 | YVL | A2 | 10 | <1–2.5 | 1.9 |
IE | BZLF1 | DPY | B7 | 4 | 1.2–1.8 | 1.7 |
E | BMLF1 | GLC | A2 | 8 | 7–11 | 9.1 |
E | BMRF1 | TLD | A2 | 5 | 3.2–10 | 6 |
E | BNLF2b | RPG | B7 | 4 | 4.5–7 | 6 |
L | BALF4 | FLD | A2 | 8 | 10–25 | 13.5 |
L | BNRF1 | WQW | A2 | 4 | 5.7–16 | 12.2 |
L | BNRF1 | YPR | B7 | 4 | 9–23 | 11.3 |
* more than one effector clone specific for each epitope was used where possible. In total, six different donor LCLs were used.