. Author manuscript; available in PMC: 2015 Aug 1.

Published in final edited form as: Immunol Allergy Clin North Am. 2014 Aug;34(3):645–662. doi: 10.1016/j.iac.2014.04.011

Table 1. Pharmacogenomics of Antiviral Drugs.

Clinical Phenotypes and Drug	Alleles	Populations
*DRESS/DIHS*
Abacavir	B*57:01	European, African^{10, 11}
Nevirapine (hepatitis)	DRB101:01 (CD4%≥25) and DRB101:02	Australian, European, South African ^12-14
Nevirapine (DRESS/DIHS with rash)	Cw8 or Cw8-B14 haplotype Cw4 B35 B35:05 B35:01 CYP2B6 516 G→T +C04 CYP2B6(rs2054675,rs3786547,rs3745274)	Italian, Japanese^{15, 16} White, Black, Asian Han Chinese ^{13, 16} Asian¹³ Asian (Thai)¹⁵ European/Australia¹⁷ White, Black, Asian¹³ White, Black, Asian¹³
*Delayed Rash (non-systemic)*
Efavirenz	DRB1*01	French⁵
Nevirapine	DRB101 Cw04 B35:05; rs1576G CCHR1 status (GWAS)	French⁵ African, Asian, European, Thai^{13, 18} Thai^{15, 16}
*SJS/TEN*
Nevirapine	HLA-C*04:01 ?CYP2B6 983 T→C	African (Malawian)¹⁹ Mozambique²⁰