Figure 1. Bacterial proteins with anticancer properties. The anticancer activity of azurin, the primary focus of this article, resides, at least in part, within an extended 28-residues α helix termed p28. Full azurin as well as p28 peptide induce apoptosis and impair angiogenesis through multiple mechanisms. The phase I clinical study indicates that p28 peptide is safe and should be further considered as a promising anticancer therapeutic peptide.