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. 2014 Apr 21;289(22):15328–15339. doi: 10.1074/jbc.M114.547349

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© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 1. — PRMT5 is necessary for the induction of CXCL10 and CX3CL1, but not IL-8 or MCP-1 in TNF-α-stimulated EC. A, Western blot analysis of PRMT5 levels from control and siPRMT5 transfected cells are shown in A, and quantified at right (p < 0.01). B–E, real-time quantitative PCR was performed to measure mRNA of the following chemokines from control and siPRMT5 transfected EC. B, CXCL10 (p < 0.0001); C, CX3CL1/fractalkine (p < 0.001); D, CXCL8/IL-8 (p > 0.05); and E, CCL2/MCP1 (p > 0.05). IB, immunoblot; **, p < 0.01; ***, p < 0.005. Means are presented as S.E. from 3–4 independent experiments.