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. 2014 Apr 15;289(22):15363–15373. doi: 10.1074/jbc.M114.562785

TABLE 1.

Summary of identified Nav1.2 peptides containing PTMs

Position Residue PTM Novel ID Search engine and databasea
 Confidence (no. of hits/5 search engines)
S X G M(1) M(2)
4 Ser Phosphorylation × × × Medium (3/5)
104 Ser Phosphorylation Yes × Low (1/5)
106 Thr Phosphorylation Yes × Low (1/5)
107 Ser Phosphorylation Yes × Low (1/5)
113 Thr Phosphorylation × Low (1/5)
468 Ser Phosphorylation × × Medium (3/5)
471 Ser Phosphorylation × × × × × High (5/5)
484 Ser Phosphorylation × × × × × High (5/5)
488 Ser Phosphorylation × × Medium (3/5)
494(495) Ser(Ser) Phosphorylation Yes × Low (1/5)
553 Ser Phosphorylation × × × × High (4/5)
554 Ser Phosphorylation × × × × High (4/5)
568 Ser Phosphorylation × × × Medium (3/5)
543 (isoform 2) Ser Phosphorylation × × × Medium (3/5)
582 (isoform 2) Ser Phosphorylation × × × Medium (3/5)
589 Ser Phosphorylation × × × × × High (5/5)
665 Ser Phosphorylation Yes × Low (1/5)
686 Ser Phosphorylation Yes × × × × High (4/5)
687 Ser Phosphorylation × × × × High (4/5)
688 Ser Phosphorylation × × × × High (4/5)
689 Tyr Phosphorylation × × × Medium (3/5)
692 Ser Phosphorylation × × × × High (4/5)
706 Ser Phosphorylation × × × × High (4/5)
709 Ser Phosphorylation × × × × High (4/5)
712 Thr Phosphorylation × × × Medium (3/5)
721 Ser Phosphorylation × × × × High (4/5)
1076 Ser Phosphorylation Yes × × × × High (4/5)
1429 Tyr Phosphorylation Yes × × × × High (4/5)
1930 Ser Phosphorylation × × Medium (3/5)
1966 Thr Phosphorylation × × × × × High (5/5)
1969(1970) Thr(Thr) Phosphorylation × Low (1/5)
1971 Ser Phosphorylation × × × Medium (3/5)
1977 Ser Phosphorylation Yes × Low (1/5)
472 Arg Methylation Yes × × × × × High (5/5)
563 Arg Methylation Yes × × × Medium (3/5)
570 Arg Methylation Yes × × × Medium (3/5)

a S, searched with rat protein sequences (IPI version 3.72) by SEQUEST; X, searched with rat protein sequences (IPI version 3.72) by X!Tandem; G, searched with rat protein sequences (IPI version 3.72) by MS-GF+; M(1), searched with rat protein sequences (IPI version 3.72) by MaxQuant; M(2), searched with rat Nav1.2 protein sequences by MaxQuant.