FIGURE 4.

GroMM-elicited skin responses in human Mincle Tg mice. GroMM liposomes and empty liposomes were injected into the skin of the 3 mouse groups, and after 2 days, tissue responses were evaluated by hematoxylin and eosin staining. A, representative micrographs are shown. Scale bars, 100 μm. B, numbers of infiltrating lymphocytes (L), macrophages (M), neutrophils (N), eosinophils (E), and basophils (B) in 10 randomly selected high power fields were counted in 4 animals from each mouse group. The mean values and S.D. are shown.