FIGURE 9.

Model of KLF14 transcriptional activation of SK1 gene. Activation of SK1 gene and S1P production result from FGF2 binding to FGFR1 receptor leading to up-regulation of SK1 promoter by KLF14. In our model, activation of FGFR1 leads to the binding of KLF14 to SK1 promoter through its GC-rich site. It then recruits p300 and promotes chromatin remodeling from a transcriptionally “inactive” to “active” state by an increase in H4K8ac, H3K14ac, and H3K4me3 marks and a decrease in H3K9me3 and H3K27me3 marks.