. Author manuscript; available in PMC: 2015 Aug 1.

Published in final edited form as: Biochim Biophys Acta. 2014 Apr 18;1846(1):88–98. doi: 10.1016/j.bbcan.2014.04.006

Table 3.

Commonly known phosphatase as tumor suppressor in prostate epithelia.

Phosphatases and its isoforms	Previous symbols/synonyms	Gene family	Chromosome location

PAcP			3q21
i. PAcP	ACP-3, ACP3, Also classically as ‘ACP2’.	Histidine-dependent DSP.
ii. TM-PAcP	ACP-3, ACP3, Also classically as ‘ACP2’.	Histidine-dependent DSP.

PTEN	MMAC1, PTEN1, TEP1, BZS, MHAM.	Class I Cys-dependent DSP.	10q23

PP2A		Serine/threonine protein phosphatase
i. PPP2CA	Protein phosphatase 2, catalytic subunit, alpha isoform; PP2Calpha.	Serine/threonine protein phosphatase	5q31.1
ii. PPP2CB	Protein phosphatase 2, catalytic subunit, beta isoform; PP2Abeta.		8p12
iii. PPP2R2A	PP2A regulatory subunit B isoform alpha; B55A; PR52A; PR55A.		8p21.2
iv. PPP2R5B	PP2A, regulatory subunit B, beta isoform; PP2A, B subunit; B56B; FLJ35411; PP2A; R5 beta isoform; PR61B.		11q12
v. PPP2R2C	PP2A, regulatory subunit B, gamma isoform; IMYPNO; MGC33570; PR52; PR55G.		4p16.1
vi. PPP2R1A	PP2A, regulatory subunit A (PR 65), alpha isoform.		19q13

PHLPP
i. PHLPP1	PLEKHE1, PHLPP.	Mg²⁺/Mn²⁺-dependent protein phosphatase.	18q21.32
ii. PHLPP2	PHLPPL	Mg²⁺/Mn²⁺-dependent protein phosphatase.	16q22.2

Abbreviations: DSP, dual specificity phosphatase; MMAC1, mutated in multiple advanced cancers 1; PAcP, prostatic acid phosphatase; cPAcP, cellular PAcP; sPAcP, secretory PAcP; PP2A, protein phosphatase 2A; PHLPP, PH domain and leucine rich repeat protein phosphatase; PP2CA, protein phosphatase 2C, alpha isoform; PP2CB, protein phosphatase 2C, betaisoform; PTEN, phosphatase and tensin homolog; TM-PAcP, transmembrane PAcP.