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. Author manuscript; available in PMC: 2015 Aug 1.

Published in final edited form as: Clin Exp Metastasis. 2014 May 15;31(6):625–638. doi: 10.1007/s10585-014-9654-5

The effects of diet and chemotherapy on lung metastasis in the treatment study. (A) All mice were kept on the LF diet until the primary tumor was removed. There was no significant differences in primary tumor volumes prior to diet changes and chemotherapy(25–30 animals per diet; *, p=0.095). (B) Mice on both the ST and CO diets alone had a significantly reduced incidence of lung metastases compared to LF diet group. (n=25–30 animals per diet; *, p<0.01). Mice receiving chemotherapy (PTX) had a significantly lower incidence of lung metastases under all diet conditions (#, p<0.01, LF diet plus PTX group vs. LF diet alone, corn oil diet plus PTX group vs. corn oil diet alone, and stearate diet plus PTX group vs. stearate diet alone). (C) Both chemotherapy and the ST diet significantly reduced the number of lung metastases (PTX vs. no PTX group, p<0.01; ST vs. LF diet group, * p<0.05). Although the number of metastases was also decreased in the CO diet groups, significance was not reached. (D) Mice on CO diet plus PTX and mice on the ST diet plus PTX had significantly decreased numbers of medium and large size lung metastases compared to the LF diet mice. The number of small sized tumors was also significantly decreased in the ST diet alone and ST diet plus PTX groups compared to LF diet. (*, p<0.05)

The effects of diet and chemotherapy on lung metastasis in the treatment study. (A) All mice were kept on the LF diet until the primary tumor was removed. There was no significant differences in primary tumor volumes prior to diet changes and chemotherapy(25–30 animals per diet; *, p=0.095). (B) Mice on both the ST and CO diets alone had a significantly reduced incidence of lung metastases compared to LF diet group. (n=25–30 animals per diet; *, p<0.01). Mice receiving chemotherapy (PTX) had a significantly lower incidence of lung metastases under all diet conditions (#, p<0.01, LF diet plus PTX group vs. LF diet alone, corn oil diet plus PTX group vs. corn oil diet alone, and stearate diet plus PTX group vs. stearate diet alone). (C) Both chemotherapy and the ST diet significantly reduced the number of lung metastases (PTX vs. no PTX group, p<0.01; ST vs. LF diet group, * p<0.05). Although the number of metastases was also decreased in the CO diet groups, significance was not reached. (D) Mice on CO diet plus PTX and mice on the ST diet plus PTX had significantly decreased numbers of medium and large size lung metastases compared to the LF diet mice. The number of small sized tumors was also significantly decreased in the ST diet alone and ST diet plus PTX groups compared to LF diet. (*, p<0.05)