Figure - PMC

Skip to main content

View full-text article in PMC

. Author manuscript; available in PMC: 2015 Aug 1.

Published in final edited form as: Clin Exp Metastasis. 2014 May 15;31(6):625–638. doi: 10.1007/s10585-014-9654-5

ST diet and chemotherapy (PTX) reduce angiogenesis in lung tumors from treatment experiment. Paraffin sections were prepared from the lung metastatic tumors in all 6 cohorts, followed by CD31 immunostaining. (A–F) are representative images of CD31 immunostaining in each of the different experimental groups. Tumors from the ST diet only group and all chemotherapy groups have reduced numbers of microvessels when compared to the LF and CO only groups. (G) When microvessel density (MVD) was measured and compared by two-way ANOVA, the data again showed that in the presence of PTX chemotherapy, lung tumors from the mice fed with ST diet had significantly reduced MVD when compared to the PTX group fed with LF diet (*, p<0.01). In the absence of chemotherapy, although the MVD was decreased in both ST and CO diet groups, significant difference was not observed.

ST diet and chemotherapy (PTX) reduce angiogenesis in lung tumors from treatment experiment. Paraffin sections were prepared from the lung metastatic tumors in all 6 cohorts, followed by CD31 immunostaining. (A–F) are representative images of CD31 immunostaining in each of the different experimental groups. Tumors from the ST diet only group and all chemotherapy groups have reduced numbers of microvessels when compared to the LF and CO only groups. (G) When microvessel density (MVD) was measured and compared by two-way ANOVA, the data again showed that in the presence of PTX chemotherapy, lung tumors from the mice fed with ST diet had significantly reduced MVD when compared to the PTX group fed with LF diet (*, p<0.01). In the absence of chemotherapy, although the MVD was decreased in both ST and CO diet groups, significant difference was not observed.