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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Traffic. 2014 Jul 12;15(9):933–945. doi: 10.1111/tra.12188

Figure 2. The ERMES complex physically connects the ER to the OM.

Figure 2

(A) Schematic of the tethering between the ER and OM by the ERMES complex. Mmm1 is N-glycosylated. (B) Mitochondria-targeted GFP is expressed in wild-type or mutant cells lacking ERMES components (mmm1Δ, mmm2Δ, mdm10Δ and mdm12Δ) and observed by fluorescence microscopy. (C) Mitochondria in cells expressing C-terminally GFP-tagged Mmm1 are stained with Mitotracker and observed under a fluorescence microscope.