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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Traffic. 2014 Jul 12;15(9):933–945. doi: 10.1111/tra.12188

Figure 4. Functional model of the Ups1-Mdm35 complex.

Figure 4

(Left) High concentration of CL in the IM keeps the Ups1-Mdm35 complex close to the IM, promoting the Ups1-Mdm35 degradation by the IM-located proteases, Yme1 and Atp23. (Right) The Ups1-Mdm35 complex shuttles between the OM and IM to mediate the PA transport due to its low affinity to the IM when CL concentration is low in the IM.