Skip to main content
. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Eur J Immunol. 2014 Jun 5;44(8):2331–2339. doi: 10.1002/eji.201344179

Figure 3.

Figure 3

Herceptin-induced ADCC by CD16.NK-92 in the presence or absence of CNTO 95Ala-Ala. Specific lysis of 51Cr-labeled A375 (A) or SKBR-3 (B) cells by CD16.NK-92 (E:T=5:1) was induced by Herceptin antibodies at indicated concentrations in the presence (black circles) or absence (open circles) of 10 μg/ml of CNTO 95Ala-Ala antibody. Arrows indicate the Herceptin concentration required for half-maximal lysis (SD50). (C). CD16.NK-92 and SKBR3 cells were pre-incubated with CNTO 95AlaAla antibodies or normal human IgG at indicated concentrations, and the specific lysis of these target cells by CD16.NK-92 was induced by Herceptin antibodies at 0.04 μg/ml. The data shown are representative from two to five independent experiments with each condition tested in triplicates within every experiment. Data depicted as mean ± SD; *p<0.05, **p<0.001, ***p<0.0001 by two-tailed Student t-test.