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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2014 Jun 12;34(9):1831–1837. doi: 10.1161/ATVBAHA.114.303217

Figure 2.

Figure 2

VEGFR2 endocytosis and recycling pathways. (A) VEGFR2 trafficking requires the synectin-myosin-VI complex, which is recruited by NRP1 after receptor internalization. (B) The PDZ binding motif on NRP1 and APPL1 mediates binding to the PDZ domain of synectin. Synectin forms a complex with myosin-VI via its myosin-VI binding motif. (C) The internalized VEGFR2-NRP1 receptor complex undergoes Rab11-dependent recycling. In the absence of NRP1, VEGFR2 is degraded via Rab7-positive late endosome. (D) VEGFR2: Src activation is downstream of phosphorylation of tyrosine 951 and ERK1/2 activation is downstream of phosphorylation of tyrosine 1175. The mechanism of VEGF-induced AKT activation is unclear.