TABLE III.

Antiemetic Switch and Rescue During and Across Treatment Cycles

		Antiemetic Switch		Antiemetic Rescue
		OR (95% C.I.)	p-value	IRR (95% C.I.)	p-value
Subsequent Days Within a Cycle	Consecutive Days on Chemotherapy	0.91 (0.84–0.98)	0.009	0.99 (0.98–0.99)	0.009
	Consecutive Days after Chemotherapy	0.96 (0.93–0.98)	0.002	1.008 (1.005–1.01)	<0.001
In Subsequent Cycles: Days on Chemotherapy	1	Referent		Referent
	2	0.56 (0.37–0.83)	0.004	0.89 (0.83–0.96)	0.002
	3	0.54 (0.34–0.86)	0.01	0.92 (0.84–1.01)	0.088
	4	0.27 (0.12–0.55)	<0.001	0.81 (0.73–0.90)	<0.001
	5	0.29 (0.13–0.62)	0.001	0.77 (0.68–0.86)	<0.001
In Subsequent Cycles: Days after Chemotherapy (Non-chemo)	1	Referent		Referent
	2	0.70 (0.42–1.16)	0.165	0.95 (0.83–1.08)	0.431
	3	0.99 (0.63–1.57)	0.971	1.06 (0.94–1.19)	0.329
	4	0.70 (0.42–1.19)	0.188	1.14 (0.99–1.30)	0.051
	5	0.42 (0.18–1.00)	0.051	0.97 (0.81–1.16)	0.713
Prior antiemetic switch		–	–	1.39 (1.21–1.59)	<0.001