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. Author manuscript; available in PMC: 2015 May 7.
Published in final edited form as: Neuron. 2014 May 7;82(3):659–669. doi: 10.1016/j.neuron.2014.03.011

Figure 2. Reduced GABABR-GIRK currents in VTA DA neurons lacking SNX27 protein.

Figure 2

(A,C) Whole-cell recordings from VTA DA neurons show baclofen-activated GIRK currents (IBaclofen; 300 µM) from WT and SNX27DA KO mice. Extracellular Ba2+ (1 mM), a selective inhibitor of inwardly rectifying potassium channels (Kir), decreases IBaclofen. Outward current measured at −50 mV is plotted as a function of time. (B,D) Scatter plot of IBaclofen for indicated DA neurons. **p<0.01, one-way ANOVA with Bonferroni post hoc test.