Table 2.
Cox Proportional Hazard Models of Host and Tumor Variables on Outcomes in 217 Patientsa
| Outcome
|
||||||||
|---|---|---|---|---|---|---|---|---|
| Locoregional Recurrence (47 Events)
|
Distant Metastasis (38 Events)
|
All-Cause Mortality (147 Events)
|
Disease-Specific Mortality (56 Events)
|
|||||
| AHR (95% CI) | Events, No. | AHR (95% CI) | Events, No. | AHR (95% CI) | Events, No. | AHR (95% CI) | Events, No. | |
| Host Variables | ||||||||
|
| ||||||||
| Age, y | ||||||||
|
| ||||||||
| <75 | 1 [Reference] | 21 | 1 [Reference] | 20 | 1 [Reference] | 48 | 1 [Reference] | 27 |
|
| ||||||||
| ≥75 | 0.7 (0.4–1.4) | 26 | 0.8 (0.4–1.6) | 18 | 1.9 (1.3–2.8) | 99 | 1.2 (0.6–2.2) | 29 |
|
| ||||||||
| Sex | ||||||||
|
| ||||||||
| Female | 1 [Reference] | 12 | 1 [Reference] | 12 | 1 [Reference] | 52 | 1 [Reference] | 20 |
|
| ||||||||
| Male | 1.4 (0.7–2.8) | 35 | 1.7 (0.8–3.4) | 26 | 1.3 (0.9–1.8) | 95 | 1.2 (0.7–2.2) | 36 |
|
| ||||||||
| Immunosuppression | ||||||||
|
| ||||||||
| None | 1 [Reference] | 45 | 1 [Reference] | 37 | 1 [Reference] | 138 | 1 [Reference] | 51 |
|
| ||||||||
| Yes | 1.1 (0.2–5.3) | 2 | 0.6 (0.1–4.6) | 1 | 1.9 (0.9–4.0) | 9 | 4.9 (1.7–14.4) | 5 |
|
| ||||||||
| Tumor Variables | ||||||||
|
| ||||||||
| Anatomic site | ||||||||
|
| ||||||||
| Limbs/trunk/other | b | 24 | 1 [Reference] | 18 | 1 [Reference] | 60 | 1 [Reference] | 22 |
|
| ||||||||
| Head/neck | 23 | 1.1 (0.5–2.3) | 18 | 0.9 (0.6–1.3) | 69 | 0.9 (0.4–1.7) | 23 | |
|
| ||||||||
| Unknown | 0 | 0.1 (0.0–0.7) | 2 | 0.4 (0.2–0.9) | 18 | 0.6 (0.2–1.9) | 11 | |
|
| ||||||||
| Size, cm | ||||||||
|
| ||||||||
| ≤2 | 1 [Reference] | 19 | 1 [Reference] | 14 | 1 [Reference] | 45 | 1 [Reference] | 15 |
|
| ||||||||
| >2 | 1.7 (0.7–4.3) | 8 | 1.1 (0.4–3.1) | 6 | 0.8 (0.5–1.6) | 17 | 1.1 (0.4–2.9) | 9 |
|
| ||||||||
| Unknown | 0.7 (0.4–1.5) | 20 | 0.8 (0.4–1.8) | 18 | 1.0 (0.7–1.5) | 85 | 0.8 (0.4–1.7) | 32 |
|
| ||||||||
| Extent, at diagnosis | ||||||||
|
| ||||||||
| Local | 1 [Reference] | 27 | 1 [Reference] | 19 | 1 [Reference] | 79 | 1 [Reference] | 18 |
|
| ||||||||
| Regional | 2.9 (1.2–7.3) | 13 | 4.2 (1.6–10.7) | 12 | 2.7 (1.5–4.7) | 36 | 5.3 (2.3–12.3) | 21 |
|
| ||||||||
| Distant | 3.8 (1.3–11.4) | 7 | 3.2 (1.1–9.2) | 7 | 3.6 (2.1–6.1) | 32 | 7.0 (2.9–16.5) | 17 |
Abbreviation: AHR, adjusted hazard ratio.
a
Adjusted for all other variables listed in table, except the race variable, which is excluded due to sparse data in nonwhite strata. One individual with no staging data was excluded from all adjusted models.
The 95% CIs were calculated using the Wald method.
b
No locoregional recurrences in individuals with no known primary by definition of recurrence.