Table 3.
Joint analyses of the melanoma risk indicator ’not being vaccinated with either BCG or vaccinia’ and four co-variables of melanoma riska
| Co-variable | Vaccination | Concomitant effect (type of) | |
|---|---|---|---|
| Yes | No | ||
| Skin-type (Fitzpatrick) | |||
| III/IV | 1.00 n = 607 | 1.68 (0.93-3.05) n = 58 | |
| II | 1.80 (1.18-2.78) n = 396 | 2.15 (0.65-8.34) n = 30 | |
| I | 1.54 (1.16-2.05) n = 126 | 6.37 (3.50-19.64) n = 12 | Synergistic |
| Sunburns in life | |||
| 0 | 1.00 n = 338 | 1.51 (0.76-3.01) n = 46 | |
| 1-5 | 0.93 (0.68-1.26) n = 596 | 2.29 (1.14-4.76) n = 45 | |
| >5 | 1.39 (0.91-2.14) n = 191 | 5.30 (0.87-102.48) n = 8 | Synergistic |
| Naevi | |||
| 0 | 1.00 n = 272 | 2.51 (1.16-5.77) n = 35 | |
| 1-4 | 1.05 (0.70-1.48) n = 387 | 5.24 (1.89-17.10) n = 22 | |
| >4 | 1.56 (1.10-2.22) n = 456 | 1.71 (0.84-3.57) n = 42 | Non-cumulative |
| Freckles on arm | |||
| 0 | 1.00 N = 457 | 3.26 (1.60-6.87) n = 39 | |
| 10-20 | 1.57 (1.17-2.10) n = 426 | 2.38 (1.09-5.32) n = 31 | |
| >20 | 3.03 (2.13-4.35) n = 247 | 4.06 (1.78-10.17) n = 30 | Non-cumulative |
aCompared with ‘vaccinated with BCG and/or vaccinia’. Data expressed as Odds Ratios (95% Confidence Intervals) for melanoma risk, adjusted for centre, sex, age, and other known risk factors. n = number of cases and controls. Summarized from the FEBIM study [83].