Table 5.
Dependent Variable | Univariate GEE β | P-Value | Multivariate GEE β | P-Value |
---|---|---|---|---|
95% CI | 95% CI | |||
Nutritional Status | ||||
Weight (Kg) | 1.3 (0.32 to 2.2) | 0.009* | 1.2 (0.27 to 2.2) | 0.01 |
Albumin (g/DL) | 0.26 (−0.12 to 0.6) | 0.18 | 0.25 (−0.1 to 0.6) | 0.17 |
Performance Status | ||||
KPS | 5.8 (3.8 to 7.8) | <0.001* | 5.9 (4.0 to 7.8) | <0.001* |
QLQ-C30 | ||||
General QoL | ||||
Global | 6.3 (2.9 to 9.6) | <0.001* | 6.2 (2.7 to 9.6) | <0.001* |
General Function | ||||
Physical | 5.8 (1.8 to 9.9) | 0.005* | 5.7 (1.7 to 9.8) | 0.006* |
Role | 12.2 (5.9 to 18.4) | <0.001* | 12.1 (6.0 to 18.3) | <0.001* |
Emotional | 4.8 (1.2 to 8.3) | 0.008* | 4.7 (1.1 to 8.3) | 0.01* |
Cognitive | 1.2 (−2.5 to 4.8) | 0.53 | 1.1 (−2.5 to 4.8) | 0.54 |
Social | 6.2 (0.2 to 12.3) | 0.04* | 6.2 (0.1 to 12.2) | 0.04* |
General Symptom | ||||
Fatigue | −9.1 (−13.9 to −4.4) | <0.001* | −9.0 (−13.8 to −4.2) | <0.001* |
Nausea/ Vomiting | −7.1 (−12.0 to −2.2) | 0.005* | −7.0 (−11.6 to −2.5) | 0.002* |
Pain | −6.7 (−11.7 to −1.8) | 0.008* | −6.7 (−11.7 to −1.7) | 0.009* |
Dyspnea | −3.7 (−9.6 to 2.2) | 0.22 | −3.6 (−9.6 to 2.3) | 0.23 |
Insomnia | −6.5 (−12.2 to −0.9) | 0.02* | −6.4 (−12.1 to −0.8) | 0.02* |
Appetite Loss | −13.7 (−19.2 to −8.1) | <0.001* | −13.4 (−18.8 to −8.1) | <0.001* |
Constipation | −8.8 (−13.8 to −3.7) | 0.001* | −8.7 (−13.6 to −3.7) | 0.001* |
Diarrhea | −0.87 (−8.0 to 6.2) | 0.81 | −0.6 (−7.5 to 6.3) | 0.86 |
Financial Problems | −0.2 (−4.8 to 4.8) | 0.99 | −0.09 (−4.9 to 4.7) | 0.97 |
GEE β estimates in the table above reflect changes in the dependent variable for every 1 month increase in time.
Multivariate β estimates were adjusted for age, gender and treatment history.
*P < =0.05.
QoL scores range from 0 to 100 and have no units.
Longitudinal Generalized Estimating Equations used to analyze the data.