Table 5.

Longitudinal GEE analyses for QoL, nutritional and functional outcomes

Dependent Variable	Univariate GEE β	P-Value	Multivariate GEE β	P-Value
	95% CI		95% CI
Nutritional Status
Weight (Kg)	1.3 (0.32 to 2.2)	0.009*	1.2 (0.27 to 2.2)	0.01
Albumin (g/DL)	0.26 (−0.12 to 0.6)	0.18	0.25 (−0.1 to 0.6)	0.17
Performance Status
KPS	5.8 (3.8 to 7.8)	<0.001*	5.9 (4.0 to 7.8)	<0.001*
QLQ-C30
General QoL
Global	6.3 (2.9 to 9.6)	<0.001*	6.2 (2.7 to 9.6)	<0.001*
General Function
Physical	5.8 (1.8 to 9.9)	0.005*	5.7 (1.7 to 9.8)	0.006*
Role	12.2 (5.9 to 18.4)	<0.001*	12.1 (6.0 to 18.3)	<0.001*
Emotional	4.8 (1.2 to 8.3)	0.008*	4.7 (1.1 to 8.3)	0.01*
Cognitive	1.2 (−2.5 to 4.8)	0.53	1.1 (−2.5 to 4.8)	0.54
Social	6.2 (0.2 to 12.3)	0.04*	6.2 (0.1 to 12.2)	0.04*
General Symptom
Fatigue	−9.1 (−13.9 to −4.4)	<0.001*	−9.0 (−13.8 to −4.2)	<0.001*
Nausea/ Vomiting	−7.1 (−12.0 to −2.2)	0.005*	−7.0 (−11.6 to −2.5)	0.002*
Pain	−6.7 (−11.7 to −1.8)	0.008*	−6.7 (−11.7 to −1.7)	0.009*
Dyspnea	−3.7 (−9.6 to 2.2)	0.22	−3.6 (−9.6 to 2.3)	0.23
Insomnia	−6.5 (−12.2 to −0.9)	0.02*	−6.4 (−12.1 to −0.8)	0.02*
Appetite Loss	−13.7 (−19.2 to −8.1)	<0.001*	−13.4 (−18.8 to −8.1)	<0.001*
Constipation	−8.8 (−13.8 to −3.7)	0.001*	−8.7 (−13.6 to −3.7)	0.001*
Diarrhea	−0.87 (−8.0 to 6.2)	0.81	−0.6 (−7.5 to 6.3)	0.86
Financial Problems	−0.2 (−4.8 to 4.8)	0.99	−0.09 (−4.9 to 4.7)	0.97

GEE β estimates in the table above reflect changes in the dependent variable for every 1 month increase in time.

Multivariate β estimates were adjusted for age, gender and treatment history.

*P < =0.05.

QoL scores range from 0 to 100 and have no units.

Longitudinal Generalized Estimating Equations used to analyze the data.