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. 2014 Jul 8;4:672–682. doi: 10.1016/j.fob.2014.07.002

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© 2014 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).

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Fig. 1 — Overview of SpAdK structure in two conformations. (A) SpAdK structure and its domains. (B) the crystal structure of SpAdK in complex with two mimic-substrates (Ap5A); the ATP, AMP, LID and CORE domains are colored with cyan, marine, orange and forest, respectively; Ap5A is shown by stick-view. (C) The crystal structure of native SpAdK, with ATP (light cyan), AMP (light blue), LID (light orange) and CORE (light green) domains. (D) The 2mF_o-DF_c electron density map at 1.48 A° resolution shows the Ap5A and cofactor Mg²⁺ (magenta sphere). (E) Superposition of two structures. (F) An insight view of the two mimic-substrate-binding cleft, including Mg²⁺ (magenta sphere), and 4 water molecules (red spheres). (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)